Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
نویسندگان
چکیده
منابع مشابه
Copy number variation analysis in the great apes reveals species-specific patterns of structural variation.
Copy number variants (CNVs) are increasingly acknowledged as an important source of evolutionary novelties in the human lineage. However, our understanding of their significance is still hindered by the lack of primate CNV data. We performed intraspecific comparative genomic hybridizations to identify loci harboring copy number variants in each of the four great apes: bonobos, chimpanzees, gori...
متن کاملVariation Analysis In The Great Apes Reveals Species - Specific Patterns Of Structural Variation
Sample collection A list of individuals, origins and hybridization arrays can be found in Supplementary Table S11. The geographical origins of the ancestors of our samples are sometimes unavailable. Gathering all possible information, we could determine that, among the individuals used on the oligonucleotide array, 5 chimpanzees are Central chimpanzees (Pan troglodytes troglodytes), 1 is a West...
متن کاملBIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
متن کاملPopulation-specific GSTM1 copy number variation.
As one of the major glutathione conjugation enzymes, GSTM1 detoxifies a number of drugs and xenobiotics. Its expression and activity have been shown to correlate both with cancer risks and drug resistance. Through a genome-wide association study, we identified a significant association between HapMap SNP rs366631 and GSTM1 expression. In this study, utilizing lymphoblastoid cell lines derived f...
متن کاملCopy number variation in potato - an asexually propagated autotetraploid species.
Copy number variation (CNV) has been revealed as a significant contributor to the genetic variation in humans. Although CNV has been reported in several model animal and plant species, the presence of CNV and its biological impact in polyploid species has not yet been documented. We conducted a fluorescence in situ hybridization (FISH)-based CNV survey in potato, a vegetatively propagated autot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Research
سال: 2011
ISSN: 1088-9051
DOI: 10.1101/gr.117242.110